Blar i forfatter "Gorchs, Laia"
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Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation
Gorchs, Laia; Hellevik, Turid; Bruun, Jack-Ansgar; Camilio, Ketil Andre; Al-Saad, Samer; Stuge, Tor Brynjar; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-12)Accumulating evidence supports the notion that high-dose (>5 Gy) radiotherapy (RT) regimens are triggering stronger pro-immunogenic effects than standard low-dose (2 Gy) regimens. However, the effects of RT on certain immunoregulatory elements in tumors remain unexplored. In this study, we have investigated the effects of high-dose radiotherapy (HD-RT) on the immunomodulating functions of cancer-associated ... -
Immune-modulating properties of carcinoma-associated fibroblasts and their changes during radiotherapy. In vitro study of primary non-small cell lung carcinoma-associated fibroblasts
Gorchs, Laia (Master thesis; Mastergradsoppgave, 2015-05-15)Background/aim of the study: Carcinoma-associated Fibroblasts (CAFs) comprise a heterogeneous population of cells and often represent the major cellular component of solid malignancies playing critical roles in tumor progression and metastasis. The purpose of this study was to gain more knowledge on the immunosuppressive traits of CAFs isolated from non-small cell lung carcinomas (NSCLC), and to ...